Gattermann–Koch reaction

The Gattermann–Koch reaction, named after the German chemists Ludwig Gattermann and Julius Arnold Koch,[1] in organic chemistry refers to a Friedel–Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in situ with Friedel–Crafts catalyst, namely AlCl3 to produce a benzaldehyde derivative from a benzene derivative in one step.[2] Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed.

An example would be the conversion of toluene to p-tolualdehyde.[3]

See also

References

  1. ^ Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30: 1622. doi:10.1002/cber.18970300288. 
  2. ^ LI Jie Jack (2003) (available on Google Books). Name Reactions: A Collection of Detailed Reaction Mechanisms (2nd ed.). Springer. p. 157. ISBN 3540402039. http://books.google.com/?id=6mZJ3084ouAC&pg=PA157&lpg=PA157&dq=%22gattermann+koch%22+reaction. 
  3. ^ G. H. Coleman, David Craig (1943), "p-Tolualdehyde", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv2p0583 ; Coll. Vol. 2: 583